I think this code should work but not exactly sure where to place it. Everywhere I have tried has failed so far...
add_action('init', 'woocommerce_clear_cart');
function woocommerce_clear_cart() {
global $woocommerce, $post, $wpdb;
$url = explode('/', 'http://'.$_SERVER["HTTP_HOST"] . $_SERVER["REQUEST_URI"]);
$slug=$url[4];
$postid = $wpdb->get_var("SELECT ID FROM $wpdb->posts WHERE post_status='publish' AND post_name = '$slug'");
if ($postid){
if ($postid == PRODUCTID1 || $postid == PRODUCTID2){
$woocommerce->cart->empty_cart();
}
}
}
Based on the accepted answer and the latest Woo version 2.5.1 I updated the function to be slightly cleaner using the code woo uses in class-wc-checkout.php to clear the cart
This worked like a charm for me, removes the previous product and adds the new one with the new product configuration. Cheers
Update: For WooCommerce 3.0.X
For WooCommerce version less than 3.0.X