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On Windows, when a PDF is opened in Adobe Reader, it appears to hold a lock on the file. This behavior means that if I want to re-run pdflatex to regenerate the file, I need to close it in Reader, run pdflatex, jump back to Reader, and reopen the file. Is there a way to make Reader not hold a lock while the file is open, like Preview on OSX and most other PDF readers I've used on other platforms?
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As peq mentioned, SumatraPDF (http://blog.kowalczyk.info/software/sumatrapdf/free-pdf-reader.html ) is a great solution.
As seen in this post in Adobe forum, the company considers this not to be a desirable feature but a bug.