Are vendor specific style prefixes needed any more

Question

I guess most of us are used to write common CSS3 properties with vendor specific prefixes to support all browsers, so it's not uncommon to see something like this:

border-radius: 6px;
-moz-border-radius: 6px;
-webkit-border-radius: 6px;
-o-border-radius: 6px;

I recently noticed that on most common properties the prefix is not required any more. And given the rapid update cycle of current browsers, I started to think about the necessity of keeping the prefixes - e.g. there probably are not many versions of Chrome still in the wild that do not support the native border-radius syntax.

Also I've always thought of these kind of properties as just eye candy, so I don't think there would be any problem about dropping support for the now obsolete Firefox 3.* and the likes in this regard.

So, is it safe to drop the prefixes on most common properties, namely border-radius and box-shadow?