That is the solution to make a negative from a image in C# Windows Forms without any dlls and in a effective, fast way?
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The best way to do this is directly accessing the pixels with bitmap data.
Just to add some timing details:
Performing Negate on an 8 Megapixel Image (on a 2.4 Ghz Core 2 Duo):
So, if you can't have unsafe code, then Color Matrix is much better than SetPixel.
If you are interested, here is the code for Color Matrix:
Go through all the pixels one by one (Bitmap.GetPixel() or something) and subtract the RGB values from 0xff to create a pixel of negative color. Save this pixel to a new image or onto the same image using (Bitmap.SetPixel()) at the same position.