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How can I tell if a method is running in the context of an AJAX postback (i.e as the result of a UpdatePanel (asynchronous) postback)?
According to egoldin Page.IsAsync is a very common confusion that has absolutely nothing to do with AJAX.
The correct approach is to use ScriptManager.GetCurrent ( Page ).IsInAsyncPostBack.
Use ScriptManager.GetCurrent ( Page ).IsInAsyncPostBack