Apparently with Android 2.3.4 and 3.1 one can now access USB accessories.
I have a Ardupilot Mega (based on Arduino) board with a USB cable connected to my laptop, and I can connect to it using a simple serial communications program over COM7 and 115,200 baud. This allows me into the command-line interface, and I can issue commands and get logs.
Is it possible to write an Android app that will communicate over USB to my Ardupilot Mega board?
I've seen many similar threads, but most of them were pre-USB host.
Maybe. Check out the Android Open Accessories announcement on the Android Developers Blog. The Arduino Mega ADK is compatible. Not sure about the Ardupilot Mega.
From their page:
You can check out the library described in Slick USB 2 Serial Library.
It enables common USB-to-serial adapters to work with Android devices that have USB host mode without needing to root.
http://slickdevlabs.com/
I am currently using the library in my own app, however I think you can get away with just the app that slick has on the market. There are two free apps and one is the "pro" version of one of the free ones; search slick usb in Google Play.
It does use HOST mode and you can change the baud rate to whatever you need.
usb-serial-for-android is my open source library written for exactly this need. It supports FTDI and CDC-ACM usb serial devices using Android's USB host support; no root or ADK necessary. It can talk most Arduinos.
The project is still in its early days, but the basic support has worked well enough for several projects. There is also a discussion list where you can get help.