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How does Windows with NTFS perform with large volumes of files and directories?
Is there any guidance around limits of files or directories you can place in a single directory before you run into performance problems or other issues?
E.g. is having a folder with 100,000 folders inside of it an OK thing to do?
100,000 should be fine.
I have (anecdotally) seen people having problems with many millions of files and I have had problems myself with Explorer just not having a clue how to count past 60-something thousand files, but NTFS should be good for the volumes you're talking.
In case you're wondering, the technical (and I hope theoretical) maximum number of files is: 4,294,967,295