I see some older questions about using SPDY (though the code has changed significantly since then), but no insights into how to properly leverage multiplexing and/or pipelining in OkHttp. I've gone through all the examples and have yet to see anything specifically referring to this.
Is this something that is automatically done?
It’s automatic. If you have a server that supports HTTP/2, and a client that supports HTTP/2, it’ll do the right thing.