I'm not totally sure what the difference is between setting dex option "jumbomode" to true vs adding multidex support.
Setting jumbo mode to true or multidex to true seems to fix the problem below
AGPBI: {"kind":"SIMPLE","text":"UNEXPECTED TOP-LEVEL EXCEPTION:","position":{},"original":"UNEXPECTED TOP-LEVEL EXCEPTION:"}
AGPBI: {"kind":"SIMPLE","text":"com.android.dex.DexIndexOverflowException: Cannot merge new index 65772 into a non-jumbo instruction!","position":{},"original":"com.android.dex.DexIndexOverflowException: Cannot merge new index 65772 into a non-jumbo instruction!"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.merge.InstructionTransformer.jumboCheck(InstructionTransformer.java:109)","position":{},"original":"\tat com.android.dx.merge.InstructionTransformer.jumboCheck(InstructionTransformer.java:109)"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.merge.InstructionTransformer.access$800(InstructionTransformer.java:26)","position":{},"original":"\tat com.android.dx.merge.InstructionTransformer.access$800(InstructionTransformer.java:26)"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.merge.InstructionTransformer$StringVisitor.visit(InstructionTransformer.java:72)","position":{},"original":"\tat com.android.dx.merge.InstructionTransformer$StringVisitor.visit(InstructionTransformer.java:72)"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.io.CodeReader.callVisit(CodeReader.java:114)","position":{},"original":"\tat com.android.dx.io.CodeReader.callVisit(CodeReader.java:114)"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.io.CodeReader.visitAll(CodeReader.java:89)","position":{},"original":"\tat com.android.dx.io.CodeReader.visitAll(CodeReader.java:89)"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.merge.InstructionTransformer.transform(InstructionTransformer.java:49)","position":{},"original":"\tat com.android.dx.merge.InstructionTransformer.transform(InstructionTransformer.java:49)"}
...